Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients
Identifieur interne : 002738 ( Main/Exploration ); précédent : 002737; suivant : 002739Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients
Auteurs : Erik Mullaart [Pays-Bas] ; Michael E. T. I. Boerrigter [Pays-Bas] ; Rivka Ravid [Pays-Bas] ; Dick F. Swaab [Pays-Bas] ; Jan Vijg [Pays-Bas]Source :
- Neurobiology of Aging [ 0197-4580 ] ; 1989.
Abstract
It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.
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DOI: 10.1016/0197-4580(90)90542-8
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Swaab</name></author><author><name sortKey="Vijg, Jan" sort="Vijg, Jan" uniqKey="Vijg J" first="Jan" last="Vijg">Jan Vijg</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B68E750C844CACD85DA5A5240030B4386D1F343B</idno><date when="1990" year="1990">1990</date><idno type="doi">10.1016/0197-4580(90)90542-8</idno><idno type="url">https://api.istex.fr/document/B68E750C844CACD85DA5A5240030B4386D1F343B/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">003095</idno><idno type="wicri:Area/Main/Curation">002D00</idno><idno type="wicri:Area/Main/Exploration">002738</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients</title><author><name sortKey="Mullaart, Erik" sort="Mullaart, Erik" uniqKey="Mullaart E" first="Erik" last="Mullaart">Erik Mullaart</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Molecular Biology, TNO Institute for Experimental Gerontology P.O. Box 5815, 2280 HV Rijswijk</wicri:regionArea><wicri:noRegion>2280 HV Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Boerrigter, Michael E T I" sort="Boerrigter, Michael E T I" uniqKey="Boerrigter M" first="Michael E. T. I." last="Boerrigter">Michael E. T. I. Boerrigter</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Molecular Biology, TNO Institute for Experimental Gerontology P.O. Box 5815, 2280 HV Rijswijk</wicri:regionArea><wicri:noRegion>2280 HV Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Ravid, Rivka" sort="Ravid, Rivka" uniqKey="Ravid R" first="Rivka" last="Ravid">Rivka Ravid</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO</wicri:regionArea><wicri:noRegion>1105 AZ Amsterdam ZO</wicri:noRegion></affiliation></author><author><name sortKey="Swaab, Dick F" sort="Swaab, Dick F" uniqKey="Swaab D" first="Dick F." last="Swaab">Dick F. Swaab</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO</wicri:regionArea><wicri:noRegion>1105 AZ Amsterdam ZO</wicri:noRegion></affiliation></author><author><name sortKey="Vijg, Jan" sort="Vijg, Jan" uniqKey="Vijg J" first="Jan" last="Vijg">Jan Vijg</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Requests for reprints should be addressed to Dr. J. Vijg, TNO Institute for Experimental Gerontology, P.O. Box 5815, 2280 HV Rijswijk</wicri:regionArea><wicri:noRegion>2280 HV Rijswijk</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Molecular Biology, TNO Institute for Experimental Gerontology P.O. Box 5815, 2280 HV Rijswijk</wicri:regionArea><wicri:noRegion>2280 HV Rijswijk</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Neurobiology of Aging</title><title level="j" type="abbrev">NBA</title><idno type="ISSN">0197-4580</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1989">1989</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="169">169</biblScope><biblScope unit="page" to="173">173</biblScope></imprint><idno type="ISSN">0197-4580</idno></series><idno type="istex">B68E750C844CACD85DA5A5240030B4386D1F343B</idno><idno type="DOI">10.1016/0197-4580(90)90542-8</idno><idno type="PII">0197-4580(90)90542-8</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0197-4580</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Mullaart, Erik" sort="Mullaart, Erik" uniqKey="Mullaart E" first="Erik" last="Mullaart">Erik Mullaart</name></noRegion><name sortKey="Boerrigter, Michael E T I" sort="Boerrigter, Michael E T I" uniqKey="Boerrigter M" first="Michael E. T. I." last="Boerrigter">Michael E. T. I. Boerrigter</name><name sortKey="Ravid, Rivka" sort="Ravid, Rivka" uniqKey="Ravid R" first="Rivka" last="Ravid">Rivka Ravid</name><name sortKey="Swaab, Dick F" sort="Swaab, Dick F" uniqKey="Swaab D" first="Dick F." last="Swaab">Dick F. Swaab</name><name sortKey="Vijg, Jan" sort="Vijg, Jan" uniqKey="Vijg J" first="Jan" last="Vijg">Jan Vijg</name><name sortKey="Vijg, Jan" sort="Vijg, Jan" uniqKey="Vijg J" first="Jan" last="Vijg">Jan Vijg</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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